Dr Holk leads an isolated and lonely existence in a small Dutch colony in the tropics Having fled from love and civilization his only companions now are alcohol and his work which takes him to villages ravaged by dirt fever and a strange illness which turns innocent people into madmen Amok One day he is called on by Helene Haviland who asks him to abort her lovers child before her husband returns from abroad Even though Holk is enchanted by her seductive beauty he haughtily refuses her request Rejected the woman turns to a Chinese practitioner When Holk tracks her down in a dirty dive its already too late for the two of them